Caenorhabditis Elegans as a Model Organism for Er-related Diseases
نویسندگان
چکیده
Endoplasmic reticulum (ER) is the site where nascent polypeptides fold and assemble into proteins that are secreted, targeted for expression at the plasma membrane or directed to intracellular organelles. Mutations in the ER machineries that perform the quality control, assemble the protein complexes, export or send misfolded proteins for degradation could trigger ER-related diseases. In this review, I will summarize the recent contributions of the model organism Caenorhabditis elegans towards identification and characterization of factors involved in ER-related disease pathogenesis.
منابع مشابه
Determination of the effects of food preservatives benzoic acid and sodium nitrate on lifespan, fertility and physical growth in Caenorhabditis elegans
Presently, the use of protective food additives such as benzoic acid and sodium nitrate is quite common. However, it was found that these additives, which initially appeared to be harmless, led to the emergence of a number of health problems. Cancer and diseases and deaths with no apparent causes are among the leading concerns. Therefore, the studies which can reveal the genotoxic potential of ...
متن کاملA review of the performance of zebrafish (Danio rerio) as a model organism in nanotoxicological research and its differences with other animal models
Today, nanotechnology is recognized as one of the leading sciences in the world, which manipulates atoms and molecules in order to produce valuable products. Extensive use of nanomaterials in various industrial sectors has increased the possibility of their diffusion in water bodies and the environment. Therefore, the study of toxicity of these substances is considered as one of the research ne...
متن کاملCaenorhabditis elegans: An important tool for dissecting microRNA functions.
Caenorhabditis elegans (C. elegans), a member of the phylum Nematoda, carries the evolutionarily conserved genes comparing to mammals. Due to its short lifespan and completely sequenced genome, C. elegans becomes a potentially powerful model for mechanistic studies in human diseases. In this mini review, we will outline the current understandings on C. elegans as a model organism for microRNA (...
متن کاملCaenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases
Caenorhabditis elegans has a number of distinct advantages that are useful for understanding the basis for cellular and organismal dysfunction underlying age-associated diseases of protein misfolding. Although protein aggregation, a key feature of human neurodegenerative diseases, has been typically explored in vivo at the single-cell level using cells in culture, there is now increasing eviden...
متن کاملMechanisms of aging-related proteinopathies in Caenorhabditis elegans
Aging is the most important risk factor for human neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Pathologically, these diseases are characterized by the deposition of specific protein aggregates in neurons and glia, representing the impairment of neuronal proteostasis. However, the mechanism by which aging affects the proteostasis system and promotes protein aggregatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011